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Literature summary for 3.4.17.1 extracted from
- Carboxypeptidase A4 promotes proliferation and stem cell characteristics of hepatocellular carcinoma (2019), Int. J. Exp. Pathol., 100, 133-138 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | knock-down of CPA4 decreases cancer cell proliferation of Bel-7402 cells. In serum-free culture, downregulated CPA4 suppresses the sphere formation capacities of tumour cells. Upregulated CPA4 in Hep-G2 cells increases the proliferation and sphere formation capacity. The protein expression of CD133, ALDH1 and CD44 also increases in cells with upregulated CPA4. In vivo, the overexpression of CPA4 in tumour cells that are subcutaneously injected into nude mice markedly increases the growth of the tumours | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BEL-7402 cell | liver cancer cell line, high expression level | Homo sapiens | - |
| Hep-G2 cell | low expression level | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPA4 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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